Our Technology

Current in vitro models often fail to reproduce the complex microenvironments found in native tissues. As a result, experimental findings generated in vitro frequently translate poorly to in vivo outcomes. This limitation is widely recognised as a major contributor to the high attrition rate in drug development, with estimates suggesting that bringing a new therapy to market can exceed US$2 billion.

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Many laboratories rely on naturally derived matrices such as Matrigel®, produced from Engelbreth-Holm-Swarm mouse sarcoma [1]. While widely used, these materials contain a complex and poorly defined mixture of extracellular matrix proteins and growth factors.

 

Studies have shown that the mechanical properties of Matrigel can vary by more than 50% between batches [2], while proteomic analyses indicate that approximately 47% of detected components differ from lot to lot [3].

 

As a result, each batch can effectively represent a different cellular microenvironment. This introduces a hidden variable into experiments, meaning that outcomes may change even when protocols remain identical. Researchers are often forced to repeat experiments to confirm results, delaying decisions and increasing time and cost.

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PeptiMatrix™ is a fully synthetic platform designed to overcome this variability.

 

Its chemically defined composition and consistent mechanical properties provide a stable and reproducible 3D microenvironment for cell culture, helping ensure that experimental results reflect biology rather than batch variability.

 

Explore the sections below to learn more about the PeptiMatrix™ platform.

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[1] Corning Matrigel Matrix Data Sheet

[2] Soofi et al. (2010) The elastic modulus of Matrigel as determined by atomic force microscopy

[3] Huges et al. (2010) Matrigel: a complex protein mixture required for optimal growth of cell culture

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Matrigel® is a registered trademark of Corning Incorporated. References to Matrigel are for comparative scientific discussion only.

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